ToxNetwork.com
Consulting in Toxicology, Carcinogenesis, Pharmacology, and Pharmacy Standard of Care

Harry A. Milman, Ph.D.

BOOKS

Milman, H.A. and Sell, S. (eds.), Application of Biological Markers to Carcinogen Testing, New York and London: Plenum Publishing Corp. (1983).

Freeman, G. and Milman, H.A. (eds.), Markers of Chemically Induced Cancer, New Jersey: Noyes Publications (1984).

Milman, H.A. and Weisburger, E.K. (eds.), Handbook of Carcinogen Testing, New Jersey: Noyes Publications (1985).

Milman, H.A. and Elmore, E. (eds.), Biochemical Mechanisms and Regulation of Intercellular Communication, New Jersey: Princeton Scientific Co., Inc. (1988).

Milman, H.A. and Weisburger, E. (eds.), Handbook of Carcinogen Testing, 2^nd edition, New Jersey: Noyes Publications (1994).

Cooney, D.A., Milman, H.A. and Truitt, R.: Disposable and versatile vessels for microdiffusion studies. Anal. Biochem. 41:583-589 (1971).

Cooney, D.A. and Milman, H.A.: A radiometric technique for measuring L-asparagine synthetase in picomole quantities. Biochem. J. 129:953-960 (1972).

Goldberg, A.I., Cooney, D.A., Glynn, J.P., Homan, E.R., Gaston, M.R. and Milman, H.A.: The effects of immunization to L-asparaginase on antitumor and enzymatic activity. Cancer Res. 33:256-261 (1973).

Milman, H.A. and Cooney, D.A.: The distribution of L-asparagine synthetase in the principal organs of several mammalian and avian species. Biochem. J. 142:27-35 (1974).

Cooney, D.A., Milman, H.A. and Homan, E.R.: A radiometric technique for measuring nicotinamide adenine dinucleotide in femtomole quantities. Methodology and application. Anal. Biochem. 63:528-542 (1975).

Jayaram, H.N., Cooney, D.A., Milman, H.A., Homan, E.R., King, V.M. and Cragoe, E.J.: Ethacrynic acid – an inhibitor of L-asparagine synthetase. Biochem. Pharmacol. 24:1787-1792 (1975).

Cooney, D.A., Milman, H.A., Jayaram, H.N. and Homan, E.R.: Inhibition of L-asparagine synthetase by mucochloric and mucobromic acids. Enzyme 21:524-539 (1976).

Jayaram, H.N., Cooney, D.A., Milman, H.A., Homan, E.R. and Rosenbluth, R.J.: DON, CONV and DONV I: Inhibition of L-asparagine synthetase in vitro. Biochem. Pharmacol. 25:1571-1582 (1976).

Rosenbluth, R.J., Cooney, D.A., Jayaram, H.N., Milman, H.A. and Homan, E.R.: DON, CONV and DONV II: Inhibition of L-asparagine synthetase in vivo. Biochem. Pharmacol. 25:1851-1858 (1976).

Cooney, D.A., Jayaram, H.N., Milman, H.A., Homan, E.R., Pittillo, R., Geran, R.I., Ryan, J. and Rosenbluth, R.J.: DON, CONV and DONV III: Pharmacologic and toxicologic studies. Biochem. Pharmacol. 25:1859-1870 (1976).

Cooney, D.A., Milman, H.A. and Taylor, Jr., B.: A radiometric method for the measurement of L-asparaginase at concentrations below 1x10^-5 I.U./ml. Technique and application. Biochem. Med. 15:190-205 (1976).

Cooney, D.A., Driscoll, J.S., Milman, H.A., Jayaram, H.N. and Davis, R.D.: Inhibitors of L-asparagine synthetase, in vitro. Cancer Treatment Rpts. 60:1493-1557 (1976).

Cooney, D.A., Milman, H.A., Cable, R.G., Dion, R.L., Bono, Jr., V.H., Karrer, K. and Friedel, H.P.: Maleimide: Biochemical, pharmacologic and toxicologic studies. Interaction with L-asparagine metabolism. Biochem. Pharmacol. 27:151-166 (1978).

Milman, H.A., Cooney, D.A. and Cable, R.G.: Maleimide II: Interaction with L-asparaginase from Escherichia coli. Biochem. Pharmacol. 27:824-826 (1978).

Brynes, S., Fiorina, V.J., Cooney, D.A. and Milman, H.A.: Potential antitumor agents via inhibitors of L-asparagine synthetase. Substituted sulfonamides and sulfonyl hydrazides related to L-glutamine. J. Pharmacol. Sci. 67:1550-1553 (1978).

Milman, H.A., Cooney, D.A. and Applebee, S.: A radiometric method for the measurement of L-asparagine synthetase activity: Comparison with available methods. Int. J. Biochem. 9:803-816 (1978).

Milman, H.A., Ward, J.M. and Chu, K.C.: Pancreatic carcinogenesis and naturally occurring pancreatic neoplasms of rats and mice in the NCI Carcinogenesis Testing Program. J. Environ. Pathol. Toxicol. 1:829-840 (1978).

Milman, H.A., Muth, R. and Cooney, D.A.: Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. Enzyme 24:36-47 (1979).

Milman, H.A. and Cooney, D.A.: Partial purification and properties of L-asparagine synthetase from mouse pancreas. Biochem. J. 181:51-59 (1979).

Milman, H.A., Cooney, D.A. and Young, D.M.: Role of pancreatic L-asparagine synthetase in the homeostasis of L-asparagine. Am. J. Physiol. 236:E746-E753 (1979).

Milman, H.A., Peckham, J.C., Ward, J.M. and Tarone, R.E.: Reduction of the severity of nephropathy in aging Fischer 344 rats treated with analogs of arylsulfonylurea. Toxicol. Appl. Pharmacol. 49:425-430 (1979).

Milman, H.A., Cooney, D.A. and Ward, J.M.: Inhibition of L-asparagine synthetase by mineral cations. Toxicol. Appl. Pharmacol. 50:573-580 (1979).

Milman, H.A., Cooney, D.A. and Huang, C.Y.: Studies on the mechanism of the glutamine-dependent reaction catalyzed by asparagine synthetase from mouse pancreas. J. Biol. Chem. 255:1862-1866 (1980)

Cooney, D.A., Jones, M.T., Milman, H.A., Young, D.M. and Jayaram, H.N.: Regulators of the metabolism of L-asparagine. A search for endogenous inhibitors. Int. J. Biochem. 11:519-539 (1980).

Chu, K.C. and Milman, H.A.: Review of experimental carcinogenesis by compounds related to vinyl chloride. Environ. Health Perspect. 41:211-220 (1981).

Milman, H.A., Hurley, P.M. and Auletta, A.: An overview of current efforts in short-term carcinogen testing. Environ. Health Perspect. 50:355-357 (1983).

Milman, H.A.: An overview of current research efforts on the application of biological markers to carcinogen testing. In: Application of Biological Markers to Carcinogen Testing (H.A. Milman and S. Sell, eds.), pp. 3-5, Plenum Publishing Corp., New York and London (1983).

Pal, B.C., Ross, R.H. and Milman, H.A.: Nutritional requirements and contaminant analysis of laboratory animal feeds. National Technical Information Service. PB No. EPA-560/6-83-005, Springfield, VA (1984).

Milman, H.A. and Peterson, C.: Apparent correlation between structure and carcinogenicity of phenylenediamines and related compounds. Environ. Health Perspect. 56:261-273 (1984).

Mitoma, C., Steeger, T., Jackson, S.E., Wheeler, K.P., Rogers, J.H. and Milman, H.A.: Metabolic disposition study of chlorinated hydrocarbons in rats and mice. Drug Chem. Toxicol. 8:183-194 (1985).

Tu, A.S., Murray, T.A., Hatch, K.M., Sivak, A. and Milman, H.A.: In vitro transformation of BALB/c-3T3 cells by chlorinated ethanes and ethylenes. Cancer Letters. 28:85-92 (1985).

Milman, H.A.: Use of cancer markers for detection of carcinogenicity. In: Safety Evaluation and Regulation of Chemicals 3 (F. Homburger, ed.), pp. 87-97, Karger, Basel (1986).

Story, D.L., Meierhenry, E.F., Tyson, C.A. and Milman, H.A.: Differences in rat liver enzyme-altered foci produced by chlorinated aliphatics and phenobarbital. Toxicol. Ind. Health 2:351-362 (1986).

Elmore, E., Milman, H.A. and Wyatt, G.P.: Applications of the chinese hamster V79 metabolic cooperation assay in toxicology. In: Biochemical Mechanisms and Regulation of Intercellular Communication (H.A. Milman and E. Elmore, eds.), pp. 265-292, Princeton Scientific Publishing Co., Inc., NJ (1988).

Milman, H.A., Story, D.L., Riccio, E.S., Sivak, A., Tu, A.S., Williams, G.M., Tong, C. and Tyson, C.A.: Rat liver and in vitro assays to detect initiating and promoting effects of chlorinated ethanes and ethylenes. Ann. NY Acad. Sci. 534:521-530 (1988).

Tyson, C.A., Gee, S.J., Hawk-Prather, K., Story, D.L. and Milman, H.A.: Correlation between in vivo and in vitro toxicity of some chlorinated aliphatics. Toxic. In Vitro 3:145-150 (1989).

Milman, H.A., Bosland, M.C., Walden, P.D. and Heinze, J.E.:  Evaluation of the adequacy of published studies of low dose effects of bisphenol A (BPA) on the rodent prostate for use in human risk assessment.  Regul. Toxicol. Pharmacol. 35:338-346 (2002).

Milman, H.A. and Arnold, S.B.:  Neurologic, psychological, and aggressive disturbances with sildenafil. Annals Pharmacoth. 36:1129-1134 (2002).

Milman, H.A. and Arnold, S.B.: Reply to Letter to the Editor on "Neurologic, psychological, and aggressive disturbances with sildenafil".  Annals Pharmacoth. 36:1973 (2002).

          Hotchkiss, A.K., Pyter, L.M., Gatien, M.L., Wen, J.C., Milman, H.A. and Nelson, R.J.: Aggressive behavior increases 
          after termination of sildenafil citrate treatment in mice.  Physiol. Behavior. 83:683-688 (2005).

          Milman, H.A.: Possible contribution of indomethacin to the carcinogenicity of non-genotoxic bladder carcinogens that cause
          bladder calculi.  Drug Chem. Toxicol. 30:161-166 (2007).

Milman, H.A., Guarino, A.M. and Cooney, D.A.: The distribution of L-asparagine synthetase in the organs of various marine animals. The Bulletin – Mount Desert Island Biological Laboratory, Salisbury Cove, ME. 12:68-71 (1972).

Jayaram, H., Cooney, D., Milman, H., Vadlamudi, S., Greenberg, N., Goldin, A. and Mead, J.A.R.: Inhibitors of L-asparagine synthetase of the L5178Y-resistant leukemia. Proc. Am. Assoc. Cancer Res. 14:109 (1973).

Milman, H.A., Cooney, D.A. and Young, D.M.: L-asparagine synthetase in the mammalian pancreas. Fed. Proc. 32:699 (1973).

Cooney, D.A, Milman, H.A. and Guarino, A.M.: Investigations of the biosynthesis of L-asparagine in the skate (Raja ocellata) and dogfish (Squalus acanthias). The Bulletin – Mount Desert Island Biological Laboratory, Salisbury Cove, ME. 13:27-28 (1973).

Schein, P., Cooney, D., Milman, H., McMenamin, M. and Anderson, T.: Studies on the mechanism of streptozotocin diabetogenicity. Clin. Res. 21:653 (1973).

Jayaram, H.N., Cooney, D.A., Homan, E.R., Milman, H.A. and Rosenbluth, R.: Inhibitors of L-asparagine synthetase of the L5l78Y-asparaginase resistant leukemia – II. The Pharmacologist 15:253 (1973).

Cable, R.G., Milman, H.A., King, V. and Taylor, B.: L-Asparagine synthetase: An enzymic marker for murine tumors. Proc. Am. Assoc. Cancer Res. 16:135 (1975).

Milman, H.A.: A comparative pharmacological study of L-asparagine synthetase from Leukemia 5178Y and mouse pancreas. Abstracts, XIIth Int. Cancer Congress 1:209-210 (1978).

Milman, H.A. and Ward, J.M.: Nitrofen and azinphosmethyl – pancreatic carcinogens in the Osborne Mendel rat. Abstracts, Joint Meeting of the American Pancreatic Assoc., Inc. and National Pancreatic Cancer Project (1978).

Milman, H.A.: Comparative biochemical studies with the L-glutamine-dependent reaction catalyzed by L-asparagine synthetase from Leukemia 5178Y and mouse pancreas. In: Adv. Comp. Leukemia Res. (D.S. Yohn, B.A. Lapin and J.R. Blakeslee, eds.), pp. 533-534, Elsevier North Holland, Inc., NY (1979).

Milman, H.A. and Cooney, D.A.: Inhibition of asparagine synthetase by sulfhydryl-reactive compounds. Proc. 13^th Int. Cancer Congress, p. 130 (1982).

Story, D.L., Gee, S.J., Hawk-Prather, K., Tyson, C.A., Mitoma, C. and Milman, H.A.: In vitro metabolism and cytotoxicity of chlorinated hydrocarbon solvents. The Toxicologist 3:103 (1983).

Mitoma, C., Steeger, T., Jackson, S.E. and Milman, H.A.: In vivo metabolism of chlorinated ethanes. The Toxicologist 3:103 (1983).

Riccio, E., Griffin, A., Mortelmans, K. and Milman, H.A.: A comparative mutagenicity study of volatile halogenated hydrocarbons using different metabolic activation systems. Abstracts, Environ. Mutag. Soc. Annual Mtg, p. 161 (1983).

Story, D.L., Dabbs, J.E., Tyson, C.A. and Milman, H.A.: Induction by chlorinated aliphatics of GGT⁺ foci in liver of male Osborne-Mendel rats. The Toxicologist 4:729 (1984).

Elmore, E., Milman, H.A., Korytynski-Smith, E.A. and Steele, V.E.: Ability of three structurally related chloro-phenylenediamine dyes to inhibit metabolic cooperation in V79 cells. In Vitro 20:259 (1984).

Milman, H.A., Mitoma, C., Tyson, C.A., Riccio, E.S., Sivak, A., Tu, A.S., Williams, G.M. and Tong, C.: Comparative pharmacokinetics/metabolism, carcinogenicity and mutagenicity of chlorinated ethanes and ethylenes. Abstracts, Int. Conf. on Organic Solvent Toxicity, p. 19 (1984).

Story, D.L., Dabbs, J.E., Tyson, C.A. and Milman, H.A.: Induction of GGT⁺ foci by chlorinated aliphatics in rat liver. The Pharmacologist 5:14 (1985).

Elmore, E., Lewis-Borden, M., Wyatt, G., Korytynski, E.A., Tennant, M.C. and Milman, H.A.: Evaluation of selected structurally-related phenylenediamine dyes in the V-79 metabolic cooperation assay. Abstracts, Fourth Int. Conf on Environ. Mutagens (1985).

Elmore, E., Murphy, D. and Milman, H.A.: Evaluation of selected structurally-related phenylenediamine dyes in the V-79 metabolic cooperation assay. The Toxicologist 6:37 (1986).

Milman, H.A., Mitoma, C., Tyson, C., Riccio, E.S., Sivak, A., Tu, A.S., Tong, C., Williams, G.M. and Elmore, E.: Carcinogenicity studies with chlorinated aliphatics. Abstracts, 14^th Int. Cancer Congress 1:305 (1986).

Milman, H.A., Elmore, E., Freeman, G. and Tyson, C.: Biochemical markers as short-term indicators of carcinogenicity. Abstracts, 14^th Int. Congress of Biochem. Th:49 (1988).

Wyatt, G., Wilkinson, B.P., Milman, H.A. and Elmore, E.: Activities of eighteen chemicals in the V79 metabolic cooperation assay. In Vitro 25:172a (1989).

Elmore, E., Milman, H.A., Wilkinson, B.P. and Wyatt, G.P.: Activities of selected cyclic hydrocarbons of known carcinogenicity in the V79 metabolic cooperation assay. The Toxicologist 9:121 (1989).

Milman, H.A. and Heinze, J.E.: Lack of consensus on wildlife effects caused by endocrine Disruptors. Abstracts, 2^nd Annual Meeting of the Japan Society of Endocrine Disrupters Research.  C1:97 (1999).

Milman, H.A. and Heinze, J.E.: Lack of consensus on health effects of endocrine disruptors. Abstracts, 2^nd Annual Meeting of the Japan Society of Endocrine Disrupters Research. C2:98 (1999).

Milman, H.A. and Heinze, J.E.: Lack of reproducibility of low dose effects of endocrine disruptors and limitations of short-term tests for screening and risk assessment. Abstracts, 2^nd Annual Meeting of the Japan Society of Endocrine Disrupters Research. C3:99 (1999).

Milman, H.A., Bosland, M.C., Walden, P.D. and Heinze, J.E.:  Adequacy of published in vivo studies of low dose effects of bisphenol A (BPA) for human risk assessment.  Abstracts, 3rd Annual Meeting of the Japan Society of Endocrine Disrupters Research.  PB-24:172 (2000).

Milman, H.A. and Heinze, J.E.:  Evaluation of the relationship between children's health and exposure to endocrine disrupters.  Abstracts, 3rd Annual Meeting of the Japan Society of Endocrine Disrupters Research.  PE-18:336 (2000).

        Milman, H.A.:  A review of Toxicology of the Pancreas (P.M. Pour, ed., CRC Press, Taylor & Francis 2006).  Int.
  J. Toxicol. 25:435-437 (2006).

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